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3D bio-printing/ Additive manufacturing

Posted on : 17 Jan 2020

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  • Bio-printing is an additive manufacturing process where biomaterials such as cells and growth factors are combined to create tissue-like structures that imitate natural tissues.
  • Bio-ink is used to create these structures in a layer-by-layer manner.
  • Bio-ink: Bio-ink is a combination of living cells and a compatible base, like collagen, elastin, gelatin, hyaluronan, silk, alginate or nanocellulose.
  • But the process can essentially be summarized into three key steps:
  1. Pre bio-printing involves creating the digital model that the printer will produce. The technologies used are computed tomography (CT) and magnetic resonance imaging (MRI) scans.
  2. Bio-printing is the actual printing process, where bio-ink is placed in a printer cartridge and deposition takes place based on the digital model.
  3. Post bio-printing is the mechanical and chemical stimulation of printed parts so as to create stable structures for the biological material.
  • Application:
  • Medicine and Bio-engineering: Advancements in the production of cartilage tissue for use in reconstruction and regeneration.
  • The process has potential to eradicate in future the need of organ donation and transplantation. Treatment for diseases can be tested using artificially affected tissues.
  • Bone tissue regeneration as well as prosthetics and dental applications.
  • Pharmaceutical testing and reduced need for animal trials.
  • Cosmetic surgery
  • Limitation:
    • The vasculature still has to be developed to allow lab skin to integrate with the human body’s blood vessels.
    • Stem cell engineering hasn’t yet evolved to grow all cells of an organ in a personalized way to avoid rejection by recipient’s immune.
    • Current not evolved to ensure that a lab organ works well with all other human organs.

Article Related Questions

  1. Recently, many developments have been made in the field of bio-printing. Which of the following is not a limitation of 3D bio-printing?
    1.The abundant and branched nature of the vasculature is difficult to reproduce
    2.Risk of immune rejection
    3.Accurately printing tissues on the micro-scale
    Choose the correct answer

  2. 1.1 only

    2.1 and 2 only

    3.3 only

    4.1, 2 and 3

    Right Ans : 3 only

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